Alzheimer Disease (AD) is the most common cause of dementia in older adults. The Knight ADRC’s Memory and Aging Project (MAP)(see link) studies changes in memory, thinking, and biomarkers over many years. The Fluid Biomarker Core collects, processes, analyzes and distributes fluid biomarker samples from these participants. Ongoing research focuses on changes over time in CSF measures of Aβ42, Aβ40, total tau protein and phosphorylated tau-181, neurofilament light chain, YKL-40, SNAP-25, neurogranin and VILIP-1. The lab also has a focus on blood-based AD biomarkers including plasma Aβ42/Aβ40 and neurofilament light chain.

Current research is focused into two main projects

  1. Development and validation of new CSF biomarkers for disease diagnosis and prognosis
  2. Development and validation of plasma biomarkers for clinical diagnosis and prognosis

Contact us

General inquiries about the lab:
jessicaandrews@wustl.edu

Suzanne Schindler’s email:
schindler.s.e@wustl.edu

Shipping address:
ATTN: Schindler Lab
2559 Scott Avenue
Biotechnology Building Room 304
St. Louis, MO 63110

Lab phone number:
314-273-8224