Our laboratory has focused on finding novel Alzheimer disease (AD) biomarkers or biomarker combinations associated with amyloid plaques, neurofibrillary tangles, brain atrophy, cognitive decline, and clinical dementia symptoms. Staging AD with a combination of biomarkers has been a major focus. The lab has been particularly interested in blood-based biomarkers, which have been rapid developing. The lab is committed to performing research that identifies and reduces health care disparities.
Recent publications
- Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's diseaseand Dominantly Inherited Alzheimer Network (DIAN), 2023, (Accepted/In press) In: Alzheimer's and Dementia.Research output: Contribution to journal › Article › peer-review
- Multimodal brain age estimates relate to Alzheimer disease biomarkers and cognition in early stages: a cross-sectional observational studyDominantly Inherited Alzheimer Network, 2023, In: eLife. 12, e81869.Research output: Contribution to journal › Article › peer-review
- Erratum: Comparative Analysis of Alzheimer's Disease Cerebrospinal Fluid Biomarkers Measurement by Multiplex SOMAscan Platform and Immunoassay-Based Approach (Journal of Alzheimer's Disease (2022) 89 (193–207) DOI: 10.3233/JAD-220399)Timsina, J., Gomez-Fonseca, D., Wang, L., Do, A., Western, D., Alvarez, I., Aguilar, M., Pastor, P., Henson, R. L., Herries, E., Xiong, C., Schindler, S., Fagan, A. M., Bateman, R. J., Farlow, M., Morris, J., Perrin, R. J., Moulder, K., Hassenstab, J., Voglein, J., & 4 othersChhatwal, J., Mori, H., Ju Sung, Y. & Cruchaga, C., 2023, In: Journal of Alzheimer's Disease. 91, 2, p. 911 1 p.Research output: Contribution to journal › Comment/debate
- The performance of plasma amyloid beta measurements in identifying amyloid plaques in Alzheimer’s disease: a literature reviewBrand, A. L., Lawler, P. E., Bollinger, J. G., Li, Y., Schindler, S. E., Li, M., Lopez, S., Ovod, V., Nakamura, A., Shaw, L. M., Zetterberg, H., Hansson, O. & Bateman, R. J., Dec 2022, In: Alzheimer's Research and Therapy. 14, 1, 195.Research output: Contribution to journal › Review article › peer-review
- Racial differences in longitudinal Alzheimer's disease biomarkers among cognitively normal adultsXiong, C., Luo, J., Schindler, S. E., Fagan, A. M., Benzinger, T., Hassenstab, J., Balls-Berry, J. E., Agboola, F., Grant, E., Moulder, K. L. & Morris, J. C., Dec 2022, In: Alzheimer's and Dementia. 18, 12, p. 2570-2581 12 p.Research output: Contribution to journal › Article › peer-review
- APOE ε4 genotype, amyloid-β, and sex interact to predict tau in regions of high APOE mRNA expressionAPOE ε4 genotype, amyloid-β, and sex interact to predict tau in regions of high APOE mRNA expressionDincer, A., Chen, C. D., McKay, N. S., Koenig, L. N., McCullough, A., Flores, S., Keefe, S. J., Schultz, S. A., Feldman, R. L., Joseph-Mathurin, N., Hornbeck, R. C., Cruchaga, C., Schindler, S. E., Holtzman, D. M., Morris, J. C., Fagan, A. M., Benzinger, T. L. S. & Gordon, B. A., Nov 16 2022, In: Science translational medicine. 14, 671, eabl7646.Research output: Contribution to journal › Article › peer-review
- Comparison of plasma and CSF biomarkers in predicting cognitive declineAschenbrenner, A. J., Li, Y., Henson, R. L., Volluz, K., Hassenstab, J., Verghese, P., West, T., Meyer, M. R., Kirmess, K. M., Fagan, A. M., Xiong, C., Holtzman, D., Morris, J. C., Bateman, R. J. & Schindler, S. E., Nov 2022, In: Annals of Clinical and Translational Neurology. 9, 11, p. 1739-1751 13 p.Research output: Contribution to journal › Article › peer-review
- ANA Investigates: The Future of Biomarkers in Alzheimer DiseaseSchindler, S. E., Ney, D. E., Goss, A. L. & Rabinovici, G., Aug 2022, In: Annals of neurology. 92, 2, p. 159-160 2 p.Research output: Contribution to journal › Comment/debate
- Predicting brain age from functional connectivity in symptomatic and preclinical Alzheimer diseasefor the Dominantly Inherited Alzheimer Network, Aug 1 2022, In: NeuroImage. 256, 119228.Research output: Contribution to journal › Article › peer-review
- Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament LightSchindler, S. E., Karikari, T. K., Ashton, N. J., Henson, R. L., Yarasheski, K. E., West, T., Meyer, M. R., Kirmess, K. M., Li, Y., Saef, B., Moulder, K. L., Bradford, D., Fagan, A. M., Gordon, B. A., Benzinger, T. L. S., Balls-Berry, J., Bateman, R. J., Xiong, C., Zetterberg, H., Blennow, K., & 1 othersMorris, J. C., Jul 19 2022, In: Neurology. 99, 3, p. E245-E257Research output: Contribution to journal › Article › peer-review