Our laboratory has focused on finding novel Alzheimer disease (AD) biomarkers or biomarker combinations associated with amyloid plaques, neurofibrillary tangles, brain atrophy, cognitive decline, and clinical dementia symptoms. Staging AD with a combination of biomarkers has been a major focus. The lab has been particularly interested in blood-based biomarkers, which have been rapid developing. The lab is committed to performing research that identifies and reduces health care disparities.

Recent publications

  • Proteome wide association studies of LRRK2 variants identify novel causal and druggable proteins for Parkinson’s diseaseDominantly Inherited Alzheimer Network (DIAN) Consortia, Dec 2023, In: npj Parkinson's Disease. 9, 1, 107.Research output: Contribution to journal › Article › peer-review
  • Differential impacts of road diets on driving behavior among older adults with and without preclinical Alzheimer's pathologyWisch, J. K., Kianfar, J., Carr, D. B., Dickerson, A. D., Vivoda, J., Harmon, A., Trani, J. F., Johnson, A. M., Doherty, J. M., Murphy, S. A., Domash, H., Ashraf, S., Aschenbrenner, A. J., Schindler, S. E., Benzinger, T. L. S., Morris, J. C., Ances, B. M. & Babulal, G. M., Oct 2023, In: Transportation Research Part F: Traffic Psychology and Behaviour. 98, p. 18-28 11 p.Research output: Contribution to journal › Article › peer-review
  • CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s diseaseHorie, K., Salvadó, G., Barthélemy, N. R., Janelidze, S., Li, Y., He, Y., Saef, B., Chen, C. D., Jiang, H., Strandberg, O., Pichet Binette, A., Palmqvist, S., Sato, C., Sachdev, P., Koyama, A., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Mattsson-Carlgren, N., & 5 othersStomrud, E., Ossenkoppele, R., Schindler, S. E., Hansson, O. & Bateman, R. J., Aug 2023, In: Nature medicine. 29, 8, p. 1954-1963 10 p.Research output: Contribution to journal › Article › peer-review
  • Genetic architecture of plasma Alzheimer disease biomarkersBradley, J., Gorijala, P., Schindler, S. E., Sung, Y. J., Ances, B., Ertekin-Taner, N., Younkin, S., Golde, T., Price, N., Bennett, D., Gaiteri, C., De Jager, P., Zhang, B., Schadt, E., Ehrlich, M., Haroutunian, V., Gandy, S., Iijima, K., Noggle, S., Mangravite, L., & 2 othersFernandez, M. V. & Cruchaga, C., Aug 1 2023, In: Human molecular genetics. 32, 15, p. 2532-2543 12 p.Research output: Contribution to journal › Article › peer-review
  • Apolipoprotein E O-glycosylation is associated with amyloid plaques and APOE genotypeLawler, P. E., Bollinger, J. G., Schindler, S. E., Hodge, C. R., Iglesias, N. J., Krishnan, V., Coulton, J. B., Li, Y., Holtzman, D. M. & Bateman, R. J., Jul 1 2023, In: Analytical Biochemistry. 672, 115156.Research output: Contribution to journal › Article › peer-review
  • Cross-sectional and longitudinal comparisons of biomarkers and cognition among asymptomatic middle-aged individuals with a parental history of either autosomal dominant or late-onset Alzheimer's diseaseand Dominantly Inherited Alzheimer Network (DIAN), Xiong, C., McCue, L. M., Buckles, V., Grant, E., Agboola, F., Coble, D., Bateman, R. J., Fagan, A. M., Benzinger, T. L. S., Hassenstab, J., Schindler, S. E., McDade, E., Moulder, K., Gordon, B. A., Cruchaga, C., Day, G. S., Ikeuchi, T., Suzuki, K., Allegri, R. F., & 3 othersVöglein, J., Levin, J. & Morris, J. C., Jul 2023, In: Alzheimer's and Dementia. 19, 7, p. 2923-2932 10 p.Research output: Contribution […]
  • Proteomic clusters underlie heterogeneity in preclinical Alzheimer’s disease progressionWisch, J. K., Butt, O. H., Gordon, B. A., Schindler, S. E., Fagan, A. M., Henson, R. L., Yang, C., Boerwinkle, A. H., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Cruchaga, C. & Ances, B. M., Jul 1 2023, In: Brain. 146, 7, p. 2944-2956 13 p.Research output: Contribution to journal › Article › peer-review
  • Plasma Aβ42/Aβ40 Ratios in Older People with Human Immunodeficiency VirusCooley, S. A., Nelson, B., Boerwinkle, A., Yarasheski, K. E., Kirmess, K. M., Meyer, M. R., Schindler, S. E., Morris, J. C., Fagan, A., Ances, B. M. & O’Halloran, J. A., May 15 2023, In: Clinical Infectious Diseases. 76, 10, p. 1776-1783 8 p.Research output: Contribution to journal › Article › peer-review
  • The role of cerebrospinal fluid and other biomarker modalities in the Alzheimer’s disease diagnostic revolutionSchindler, S. E. & Atri, A., May 2023, In: Nature Aging. 3, 5, p. 460-462 3 p.Research output: Contribution to journal › Comment/debate
  • Extraction of clinical phenotypes for Alzheimer's disease dementia from clinical notes using natural language processingOh, I. Y., Schindler, S. E., Ghoshal, N., Lai, A. M., Payne, P. R. O. & Gupta, A., Apr 1 2023, In: JAMIA Open. 6, 1, ooad014.Research output: Contribution to journal › Article › peer-review