Our laboratory has focused on finding novel Alzheimer disease (AD) biomarkers or biomarker combinations associated with amyloid plaques, neurofibrillary tangles, brain atrophy, cognitive decline, and clinical dementia symptoms. Staging AD with a combination of biomarkers has been a major focus. The lab has been particularly interested in blood-based biomarkers, which have been rapid developing. The lab is committed to performing research that identifies and reduces health care disparities.
Featured publications
Using Alzheimer’s disease blood tests to accelerate clinical trial enrollment
April 1, 2023
Schindler SE, Li Y, Li M, Despotis A, Park E, Vittert L, Hamilton BH, Womack KB, Saef B, Holtzman DM, Morris JC, Bateman RJ, Gupta MR. Using Alzheimer’s disease blood tests to accelerate clinical trial enrollment. Alzheimers Dement. 2023 Apr;19(4):1175-1183. doi: 10.1002/alz.12754. Epub 2022 Aug 7. PMID: 35934777; PMCID: PMC9902574.
CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease
March 13, 2023
Barthélemy NR, Saef B, Li Y, Gordon BA, He Y, Horie K, Stomrud E, Salvadó G, Janelidze S, Sato C, Ovod V, Henson RL, Fagan AM, Benzinger TLS, Xiong C, Morris JC, Hansson O, Bateman RJ, Schindler SE. CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease. Nat Aging. 2023 Apr;3(4):391-401. doi: 10.1038/s43587-023-00380-7. Epub 2023 Mar 13. PMID: 37117788; PMCID: PMC10154225.
Predicting continuous amyloid PET values with CSF and plasma Aβ42/Aβ40
March 2, 2023
Wisch JK, Gordon BA, Boerwinkle AH, Luckett PH, Bollinger JG, Ovod V, Li Y, Henson RL, West T, Meyer MR, Kirmess KM, Benzinger TLS, Fagan AM, Morris JC, Bateman RJ, Ances BM, Schindler SE. Predicting continuous amyloid PET values with CSF and plasma Aβ42/Aβ40. Alzheimers Dement (Amst). 2023 Mar 2;15(1):e12405. doi: 10.1002/dad2.12405. PMID: 36874595; PMCID: PMC9980305.
Comparison of plasma and CSF biomarkers in predicting cognitive decline
November 1, 2022
Aschenbrenner AJ, Li Y, Henson RL, Volluz K, Hassenstab J, Verghese P, West T, Meyer MR, Kirmess KM, Fagan AM, Xiong C, Holtzman D, Morris JC, Bateman RJ, Schindler SE. Comparison of plasma and CSF biomarkers in predicting cognitive decline. Ann Clin Transl Neurol. 2022 Nov;9(11):1739-1751. doi: 10.1002/acn3.51670. Epub 2022 Oct 2. PMID: 36183195; PMCID: PMC9639639.
Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament Light
July 19, 2022
Schindler SE, Karikari TK, Ashton NJ, Henson RL, Yarasheski KE, West T, Meyer MR, Kirmess KM, Li Y, Saef B, Moulder KL, Bradford D, Fagan AM, Gordon BA, Benzinger TLS, Balls-Berry J, Bateman RJ, Xiong C, Zetterberg H, Blennow K, Morris JC. Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament Light. Neurology. 2022 Jul 19;99(3):e245-e257. doi: 10.1212/WNL.0000000000200358. Epub 2022 Apr 21. PMID: 35450967; PMCID: PMC9302933.
Predicting Symptom Onset in Sporadic Alzheimer Disease With Amyloid PET
November 2, 2021
Schindler SE, Li Y, Buckles VD, Gordon BA, Benzinger TLS, Wang G, Coble D, Klunk WE, Fagan AM, Holtzman DM, Bateman RJ, Morris JC, Xiong C. Predicting Symptom Onset in Sporadic Alzheimer Disease With Amyloid PET. Neurology. 2021 Nov 2;97(18):e1823-e1834. doi: 10.1212/WNL.0000000000012775. Epub 2021 Sep 9. PMID: 34504028; PMCID: PMC8610624.
High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis
October 22, 2019
Schindler SE, Bollinger JG, Ovod V, Mawuenyega KG, Li Y, Gordon BA, Holtzman DM, Morris JC, Benzinger TLS, Xiong C, Fagan AM, Bateman RJ. High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis. Neurology. 2019 Oct 22;93(17):e1647-e1659. doi: 10.1212/WNL.0000000000008081. Epub 2019 Aug 1. PMID: 31371569; PMCID: PMC6946467.
Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer’s disease
May 1, 2019
Schindler SE, Li Y, Todd KW, Herries EM, Henson RL, Gray JD, Wang G, Graham DL, Shaw LM, Trojanowski JQ, Hassenstab JJ, Benzinger TLS, Cruchaga C, Jucker M, Levin J, Chhatwal JP, Noble JM, Ringman JM, Graff-Radford NR, Holtzman DM, Ladenson JH, Morris JC, Bateman RJ, Xiong C, Fagan AM; Dominantly Inherited Alzheimer Network. Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer’s disease. Alzheimers Dement. 2019 May;15(5):655-665. doi: 10.1016/j.jalz.2018.12.019. Epub 2019 Mar 4. PMID: 30846386; PMCID: PMC6511459.
Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging
November 1, 2018
Schindler SE, Gray JD, Gordon BA, Xiong C, Batrla-Utermann R, Quan M, Wahl S, Benzinger TLS, Holtzman DM, Morris JC, Fagan AM. Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging. Alzheimers Dement. 2018 Nov;14(11):1460-1469. doi: 10.1016/j.jalz.2018.01.013. Epub 2018 Mar 2. PMID: 29501462; PMCID: PMC6119652.
Recent publications
- Novel avenues of tau researchSexton, C. E., Bitan, G., Bowles, K. R., Brys, M., Buée, L., Maina, M. B., Clelland, C. D., Cohen, A. D., Crary, J. F., Dage, J. L., Diaz, K., Frost, B., Gan, L., Goate, A. M., Golbe, L. I., Hansson, O., Karch, C. M., Kolb, H. C., La Joie, R., Lee, S. E., & 16 othersMatallana, D., Miller, B. L., Onyike, C. U., Quiroz, Y. T., Rexach, J. E., Rohrer, J. D., Rommel, A., Sadri-Vakili, G., Schindler, S. E., Schneider, J. A., Sperling, R. A., Teunissen, C. E., Weninger, S. C., Worley, S. L., Zheng, H. […]
- Relationships of Cognitive Measures with Cerebrospinal Fluid but Not Imaging Biomarkers of Alzheimer Disease Vary between Black and White IndividualsBonomi, S., Lu, R., Schindler, S. E., Bui, Q., Lah, J. J., Wolk, D., Gleason, C. E., Sperling, R., Roberson, E. D., Levey, A. I., Shaw, L., Van Hulle, C., Benzinger, T., Adams, M., Manzanares, C., Qiu, D., Hassenstab, J., Moulder, K. L., Balls-Berry, J. E., Johnson, K., & 16 othersJohnson, S. C., Murchison, C. F., Luo, J., Gremminger, E., Agboola, F., Grant, E. A., Hornbeck, R., Massoumzadeh, P., Keefe, S., Dierker, D., Gray, J., Henson, R. L., Streitz, M., Mechanic-Hamilton, […]
- Predictors and outcomes of fluctuations in the clinical dementia rating scaleWilks, H., Benzinger, T. L. S., Schindler, S. E., Cruchaga, C., Morris, J. C. & Hassenstab, J., Mar 2024, In: Alzheimer's and Dementia. 20, 3, p. 2080-2088 9 p.Research output: Contribution to journal › Article › peer-review
- Sex-specific patterns of body mass index relationship with white matter connectivityRahmani, F., Wang, Q., McKay, N. S., Keefe, S., Hantler, N., Hornbeck, R., Wang, Y., Hassenstab, J., Schindler, S., Xiong, C., Morris, J., Benzinger, T. L. S. & Raji, C. A., Feb 20 2024, Handbook of Prevention and Alzheimer's Disease. IOS Press, p. 457-474 18 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
- Investigating White Matter Neuroinflammation in Alzheimer Disease Using Diffusion-Based Neuroinflammation ImagingWang, Q., Schindler, S. E., Chen, G., Mckay, N. S., McCullough, A., Flores, S., Liu, J., Sun, Z., Wang, S., Wang, W., Hassenstab, J., Cruchaga, C., Perrin, R. J., Fagan, A. M., Morris, J. C., Wang, Y. & Benzinger, T. L. S., Feb 1 2024, In: Neurology. 102, 4, p. e208013Research output: Contribution to journal › Article › peer-review
- Correlational analyses of biomarkers that are harmonized through a bridging study due to measurement errorsXiong, C., Schindler, S. E., Henson, R. L., Wolk, D. A., Shaw, L. M., Agboola, F., Morris, J. C., Lu, R. & Luo, J., Feb 2024, In: Statistical Methods in Medical Research. 33, 2, p. 185-202 18 p.Research output: Contribution to journal › Article › peer-review
- Diagnostic Utility of Cerebrospinal Fluid Biomarkers in Patients with Rapidly Progressive DementiaKuchenbecker, L. A., Tipton, P. W., Martens, Y., Brier, M. R., Satyadev, N., Dunham, S. R., Lazar, E. B., Dacquel, M. V., Henson, R. L., Bu, G., Geschwind, M. D., Morris, J. C., Schindler, S. E., Herries, E., Graff-Radford, N. R. & Day, G. S., Feb 2024, In: Annals of neurology. 95, 2, p. 299-313 15 p.Research output: Contribution to journal › Article › peer-review
- Disease staging of Alzheimer’s disease using a CSF-based biomarker modelSalvadó, G., Horie, K., Barthélemy, N. R., Vogel, J. W., Pichet Binette, A., Chen, C. D., Aschenbrenner, A. J., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Palmqvist, S., Stomrud, E., Janelidze, S., Ossenkoppele, R., Schindler, S. E., Bateman, R. J. & Hansson, O., 2024, (Accepted/In press) In: Nature Aging.Research output: Contribution to journal › Article › peer-review
- Timing of Biomarker Changes in Sporadic Alzheimer's Disease in Estimated Years from Symptom OnsetLi, Y., Yen, D., Hendrix, R., Gordon, B., Dlamini, S., Barthélemy, N. R., Aschenbrenner, A. J., Henson, R. L., Herries, E. M., Volluz, K., Kirmess, K., Eastwood, S., Meyer, M., Heller, M., Jarrett, L., McDade, E., Holtzman, D. M., Benzinger, T. L. S., Morris, J., Bateman, R. J., & 2 othersXiong, C. & Schindler, S., 2024, (Accepted/In press) In: Annals of neurology.Research output: Contribution to journal › Article › peer-review
- Naturalistic assessment of reaction time variability in older adults at risk for Alzheimer's diseaseNaturalistic assessment of reaction time variability in older adults at risk for Alzheimer's diseaseWelhaf, M. S., Wilks, H., Aschenbrenner, A. J., Balota, D. A., Schindler, S. E., Benzinger, T. L. S., Gordon, B. A., Cruchaga, C., Xiong, C., Morris, J. C. & Hassenstab, J., 2024, (Accepted/In press) In: Journal of the International Neuropsychological Society.Research output: Contribution to journal › Article › peer-review