Our laboratory has focused on finding novel Alzheimer disease (AD) biomarkers or biomarker combinations associated with amyloid plaques, neurofibrillary tangles, brain atrophy, cognitive decline, and clinical dementia symptoms. Staging AD with a combination of biomarkers has been a major focus. The lab has been particularly interested in blood-based biomarkers, which have been rapid developing. The lab is committed to performing research that identifies and reduces health care disparities.
Featured publications
Acceptable performance of blood biomarker tests of amyloid pathology – recommendations from the Global CEO Initiative on Alzheimer’s Disease
July 1, 2024
Schindler SE, Galasko D, Pereira AC, Rabinovici GD, Salloway S, Suárez-Calvet M, Khachaturian AS, Mielke MM, Udeh-Momoh C, Weiss J, Batrla R, Bozeat S, Dwyer JR, Holzapfel D, Jones DR, Murray JF, Partrick KA, Scholler E, Vradenburg G, Young D, Algeciras-Schimnich A, Aubrecht J, Braunstein JB, Hendrix J, Hu YH, Mattke S, Monane M, Reilly D, Somers E, Teunissen CE, Shobin E, Vanderstichele H, Weiner MW, Wilson D, Hansson O. Acceptable performance of blood biomarker tests of amyloid pathology – recommendations from the Global CEO Initiative on Alzheimer’s Disease. Nat Rev Neurol. 2024 Jul;20(7):426-439. doi: 10.1038/s41582-024-00977-5. Epub 2024 Jun 12. PMID: 38866966.
See related video: CEOi BBM Workgroup, Suzanne Schindler feature
Using Alzheimer’s disease blood tests to accelerate clinical trial enrollment
April 1, 2023
Schindler SE, Li Y, Li M, Despotis A, Park E, Vittert L, Hamilton BH, Womack KB, Saef B, Holtzman DM, Morris JC, Bateman RJ, Gupta MR. Using Alzheimer’s disease blood tests to accelerate clinical trial enrollment. Alzheimers Dement. 2023 Apr;19(4):1175-1183. doi: 10.1002/alz.12754. Epub 2022 Aug 7. PMID: 35934777; PMCID: PMC9902574.
CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease
March 13, 2023
Barthélemy NR, Saef B, Li Y, Gordon BA, He Y, Horie K, Stomrud E, Salvadó G, Janelidze S, Sato C, Ovod V, Henson RL, Fagan AM, Benzinger TLS, Xiong C, Morris JC, Hansson O, Bateman RJ, Schindler SE. CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease. Nat Aging. 2023 Apr;3(4):391-401. doi: 10.1038/s43587-023-00380-7. Epub 2023 Mar 13. PMID: 37117788; PMCID: PMC10154225.
Predicting continuous amyloid PET values with CSF and plasma Aβ42/Aβ40
March 2, 2023
Wisch JK, Gordon BA, Boerwinkle AH, Luckett PH, Bollinger JG, Ovod V, Li Y, Henson RL, West T, Meyer MR, Kirmess KM, Benzinger TLS, Fagan AM, Morris JC, Bateman RJ, Ances BM, Schindler SE. Predicting continuous amyloid PET values with CSF and plasma Aβ42/Aβ40. Alzheimers Dement (Amst). 2023 Mar 2;15(1):e12405. doi: 10.1002/dad2.12405. PMID: 36874595; PMCID: PMC9980305.
Comparison of plasma and CSF biomarkers in predicting cognitive decline
November 1, 2022
Aschenbrenner AJ, Li Y, Henson RL, Volluz K, Hassenstab J, Verghese P, West T, Meyer MR, Kirmess KM, Fagan AM, Xiong C, Holtzman D, Morris JC, Bateman RJ, Schindler SE. Comparison of plasma and CSF biomarkers in predicting cognitive decline. Ann Clin Transl Neurol. 2022 Nov;9(11):1739-1751. doi: 10.1002/acn3.51670. Epub 2022 Oct 2. PMID: 36183195; PMCID: PMC9639639.
Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament Light
July 19, 2022
Schindler SE, Karikari TK, Ashton NJ, Henson RL, Yarasheski KE, West T, Meyer MR, Kirmess KM, Li Y, Saef B, Moulder KL, Bradford D, Fagan AM, Gordon BA, Benzinger TLS, Balls-Berry J, Bateman RJ, Xiong C, Zetterberg H, Blennow K, Morris JC. Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament Light. Neurology. 2022 Jul 19;99(3):e245-e257. doi: 10.1212/WNL.0000000000200358. Epub 2022 Apr 21. PMID: 35450967; PMCID: PMC9302933.
Predicting Symptom Onset in Sporadic Alzheimer Disease With Amyloid PET
November 2, 2021
Schindler SE, Li Y, Buckles VD, Gordon BA, Benzinger TLS, Wang G, Coble D, Klunk WE, Fagan AM, Holtzman DM, Bateman RJ, Morris JC, Xiong C. Predicting Symptom Onset in Sporadic Alzheimer Disease With Amyloid PET. Neurology. 2021 Nov 2;97(18):e1823-e1834. doi: 10.1212/WNL.0000000000012775. Epub 2021 Sep 9. PMID: 34504028; PMCID: PMC8610624.
High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis
October 22, 2019
Schindler SE, Bollinger JG, Ovod V, Mawuenyega KG, Li Y, Gordon BA, Holtzman DM, Morris JC, Benzinger TLS, Xiong C, Fagan AM, Bateman RJ. High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis. Neurology. 2019 Oct 22;93(17):e1647-e1659. doi: 10.1212/WNL.0000000000008081. Epub 2019 Aug 1. PMID: 31371569; PMCID: PMC6946467.
Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer’s disease
May 1, 2019
Schindler SE, Li Y, Todd KW, Herries EM, Henson RL, Gray JD, Wang G, Graham DL, Shaw LM, Trojanowski JQ, Hassenstab JJ, Benzinger TLS, Cruchaga C, Jucker M, Levin J, Chhatwal JP, Noble JM, Ringman JM, Graff-Radford NR, Holtzman DM, Ladenson JH, Morris JC, Bateman RJ, Xiong C, Fagan AM; Dominantly Inherited Alzheimer Network. Emerging cerebrospinal fluid biomarkers in autosomal dominant Alzheimer’s disease. Alzheimers Dement. 2019 May;15(5):655-665. doi: 10.1016/j.jalz.2018.12.019. Epub 2019 Mar 4. PMID: 30846386; PMCID: PMC6511459.
Recent publications
- Free Recall Outperforms Story Recall in Associations with Plasma Biomarkers in Preclinical Alzheimer DiseaseAschenbrenner, A., Hassenstab, J. J., Schindler, S. E., Janelidze, S., Hansson, O., Morris, J. C. & Grober, E., Dec 2024, In: The journal of prevention of Alzheimer's disease. 11, 6, p. 1696-1702 7 p.Research output: Contribution to journal › Article › peer-review
- Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individualsXiong, C., Luo, J., Wolk, D. A., Shaw, L. M., Roberson, E. D., Murchison, C. F., Henson, R. L., Benzinger, T. L. S., Bui, Q., Agboola, F., Grant, E., Gremminger, E. N., Moulder, K. L., Geldmacher, D. S., Clay, O. J., Babulal, G., Cruchaga, C., Holtzman, D. M., Bateman, R. J. & Morris, J. C. & 1 others, Schindler, S. E., Dec 2024, In: Nature communications. 15, 1, 5539.Research output: Contribution to journal › Article › peer-review
- Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research CenterFernandez, M. V., Liu, M., Beric, A., Johnson, M., Cetin, A., Patel, M., Budde, J., Kohlfeld, P., Bergmann, K., Lowery, J., Flynn, A., Brock, W., Sanchez Montejo, B., Gentsch, J., Sykora, N., Norton, J., Gentsch, J., Valdez, O., Gorijala, P. & Sanford, J. & 24 others, Sun, Y., Wang, C., Western, D., Timsina, J., Mangetti Goncalves, T., Do, A. N., Sung, Y. J., Zhao, G., Morris, J. C., Moulder, K., Holtzman, D. M., Bateman, R. J., Karch, C., Hassenstab, J., Xiong, C., Schindler, S. […]
- An interpretable machine learning-based cerebrospinal fluid proteomics clock for predicting age reveals novel insights into brain agingMelendez, J., Sung, Y. J., Orr, M., Yoo, A., Schindler, S., Cruchaga, C. & Bateman, R., Sep 2024, In: Aging Cell. 23, 9, e14230.Research output: Contribution to journal › Article › peer-review
- Unexpected Low Rate of Amyloid-β Pathology in Multiple Sclerosis PatientsBrier, M. R., Schindler, S. E., Salter, A., Perantie, D., Shelley, N., Judge, B., Keefe, S., Kirmess, K. M., Verghese, P. B., Yarasheski, K. E., Venkatesh, V., Raji, C. A., Gordon, B. A., Bateman, R. J., Morris, J. C., Naismith, R. T., Holtzman, D. M., Benzinger, T. L. S. & Cross, A. H., Sep 2024, In: Annals of neurology. 96, 3, p. 453-459 7 p.Research output: Contribution to journal › Article › peer-review
- Predicting continuous amyloid PET values with CSF tau phosphorylation occupanciesWisch, J. K., Gordon, B. A., Barthélemy, N. R., Horie, K., Henson, R. L., He, Y., Flores, S., Benzinger, T. L. S., Morris, J. C., Bateman, R. J., Ances, B. M. & Schindler, S. E., Sep 2024, In: Alzheimer's and Dementia. 20, 9, p. 6365-6373 9 p.Research output: Contribution to journal › Article › peer-review
- A genetic and proteomic comparison of key AD biomarkers across tissuesDominantly Inherited Alzheimer Network, Marsh, T. W., Western, D., Timsina, J., Gorijala, P., Yang, C., Pastor, P., Liu, M., Morris, J. C., Bateman, R. J., Schindler, S. E., Sung, Y. J. & Cruchaga, C., Sep 2024, In: Alzheimer's and Dementia. 20, 9, p. 6423-6440 18 p.Research output: Contribution to journal › Article › peer-review
- Cognition Mediates the Association between Cerebrospinal Fluid Biomarkers of Amyloid and P-Tau and Neuropsychiatric SymptomsFrank, B., Walsh, M., Hurley, L., Groh, J., Blennow, K., Zetterberg, H., Tripodis, Y., Budson, A. E., O'Connor, M. K., Martin, B., Weller, J., McKee, A., Qiu, W., Stein, T. D., Stern, R. A., Mez, J., Henson, R., Long, J., Aschenbrenner, A. J. & Babulal, G. M. & 3 others, Morris, J. C., Schindler, S. & Alosco, M. L., Jul 30 2024, In: Journal of Alzheimer's Disease. 100, 3, p. 1055-1073 19 p.Research output: Contribution to journal › Article › peer-review
- Naturalistic assessment of reaction time variability in older adults at risk for Alzheimer's diseaseNaturalistic assessment of reaction time variability in older adults at risk for Alzheimer's diseaseWelhaf, M. S., Wilks, H., Aschenbrenner, A. J., Balota, D. A., Schindler, S. E., Benzinger, T. L. S., Gordon, B. A., Cruchaga, C., Xiong, C., Morris, J. C. & Hassenstab, J., Jun 29 2024, In: Journal of the International Neuropsychological Society. 30, 5, p. 428-438 11 p.Research output: Contribution to journal › Article › peer-review
- Disease staging of Alzheimer’s disease using a CSF-based biomarker modelSalvadó, G., Horie, K., Barthélemy, N. R., Vogel, J. W., Pichet Binette, A., Chen, C. D., Aschenbrenner, A. J., Gordon, B. A., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C., Palmqvist, S., Stomrud, E., Janelidze, S., Ossenkoppele, R., Schindler, S. E., Bateman, R. J. & Hansson, O., May 2024, In: Nature Aging. 4, 5, p. 694-708 15 p.Research output: Contribution to journal › Article › peer-review